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2021-05-26

What is the pathophysiology of multiple sclerosis?

What is the pathophysiology of multiple sclerosis?

The underlying pathophysiology hallmarks are inflammatory lesions that result in neuronal demyelination, axonal damage and subsequent neurological dysfunctions following the formation of multiple plaques in the grey and white matter of the brain and spinal cord (9).

What is the pathophysiology of cystic fibrosis?

CF is caused by a mutation in the CF transmembrane conductance regulator (CFTR) gene. The CFTR protein produced by this gene regulates the movement of chloride and sodium ions across epithelial cell membranes.

How does cystic fibrosis affect daily life?

Some people with cystic fibrosis experience depression. According to a 2008 study , cystic fibrosis is a risk factor for depression. The study showed that depression in people with cystic fibrosis may have a negative impact on their treatment, family life, and health-related quality of life.

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How does cystic fibrosis impact family members?

Parents of children with cystic fibrosis are more likely to experience anxiety, depression, or both compared to parents in general.

How is cystic fibrosis monitored?

The sweat test is the standard test for diagnosing cystic fibrosis. It may be used if you have symptoms that may indicate cystic fibrosis, or to confirm a positive diagnosis from a screening of your newborn baby. A normal sweat chloride test alone does not mean you do not have cystic fibrosis.

What it feels like to have cystic fibrosis?

The thick and sticky mucus associated with cystic fibrosis clogs the tubes that carry air in and out of your lungs. This can cause signs and symptoms such as: A persistent cough that produces thick mucus (sputum) Wheezing.

Can you have CF with no symptoms?

While cystic fibrosis is usually diagnosed in childhood, adults with no symptoms (or mild symptoms) during their youth can still be found to have the disease.

What is cystic fibrosis exactly?

Cystic fibrosis is a progressive, genetic disease that causes persistent lung infections and limits the ability to breathe over time. In people with CF, mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause the CFTR protein to become dysfunctional.

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Why do CF patients have to stay 5 feet apart?

What is the 6-foot rule? In people with CF, the mucus in the lungs can trap bacteria, causing infection. These infections can be dangerous – even life-threatening – to people with CF. This is why doctors say that patients with CF should stay 6 feet (or more) away from anyone who is sick.

What gender is most affected by cystic fibrosis?

How Are Men Affected by Cystic Fibrosis? Males account for slightly more than 50 percent of all cases of cystic fibrosis (CF) but generally have better outcomes than females until about age 20. After that, men and women experience roughly equal outcomes for long-term survival.

What are the symptoms of cystic fibrosis in a child?

What Are the Signs & Symptoms of Cystic Fibrosis?

  • lung infections or pneumonia.
  • wheezing.
  • coughing with thick mucus.
  • bulky, greasy bowel movements.
  • constipation or diarrhea.
  • trouble gaining weight or poor height growth.
  • very salty sweat.

What is the newborn screening test for cystic fibrosis?

Every state’s CF newborn screening program begins with a blood test from the baby to check the levels of a chemical made by the pancreas called immunoreactive trypsinogen (IRT). Did You Know? All 50 states perform newborn screening for cystic fibrosis. IRT is normally found in small levels in the body.